Formulation and Evaluation of Colon Targeted Mucoadhesive Microsphere of Aceclofenac

The aim of this research was to formulate and evaluate colon-targeted mucoadhesive microspheres of aceclofenac, an anti-inflammatory drug, to enhance its bioavailability and reduce gastrointestinal side effects. Aceclofenac-loaded microspheres were prepared using a variety of mucoadhesive polymers such as chitosan, sodium alginate, and Eudragit. The prepared microspheres were characterized for particle size, surface morphology, drug encapsulation efficiency, in vitro drug release, and mucoadhesion properties. The optimized formulation demonstrated a sustained drug release profile, efficient mucoadhesion, and enhanced stability in simulated colonic fluid. The findings suggest that mucoadhesive microspheres are a promising carrier for the targeted delivery of aceclofenac to the colon.