A Derivative Spectrophotometric Method for the Vierordt’s Detection of Terbinafine and Itraconazole in Topical Dosage Form

The goal of the current work was to simultaneously estimate the dosage forms of pharmaceutical topical dosage form and bulk itraconazole and terbinafine HCl by developing and validating a novel and straight forward UV spectrophotometric approach. As of right now, no reports of this medication combination for simultaneous UV spectrophotometric analysis exist. Acetonitrile was utilized as a solvent in the UV Shimadzu 1800 model, which was employed to test the developed approach. For Terbinafine HCl, the wavelength at which the λmax was measured was 235 nm, while for itraconazole, it was 263 nm. It was discovered that the percent RSD of both the system and technique precision for itraconazole and terbinafine HCl was less than 2%. In summary, a new and straightforward UV spectrophotometric technique was created and verified for the simultaneous measurement of terbinafine HCl and itraconazole in pharmaceutical topical dosage form and bulk dose forms. The created approach was determined to be precise, accurate, linear, and stable because the results were found to be within the given range.