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ArticlePeer ReviewedOpen AccessPlagiarism Passed
Paper ID:10.55041/IJSREM35538

A NOVEL SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF RANOLAZINE IN BULK DRUG AND IT’S FORMULATION

Stream/Area:

-

Subject:

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Paper ID:

10.55041/IJSREM35538

Volume:

8 |

6 |

Jun 2024

Pages:

Publication Frequency:

Monthly (12 issues per year)

DOI
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10.55041/IJSREM35538

License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.

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Authors

PP

Patlolla Pravalika

ASKG

Ankilla Sri Krishna Goud

NRGMR

Narayana Reddy Gari Manasa Reddy

GTSD

Gopa Tejasri Sathya Durga

TRR

Tadikonda Rama Rao

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Abstract

The simple, rapid, precise, accurate, robust and economical analytical method has been developed for estimation of Ranolazine in bulk and pharmaceutical dosage form. This study describes the validation of an UV Spectrophotometric method for quantitative determination of Ranolazine in pharmaceutical dosage form using acetate buffer (pH 4.4) as solvent. The maximum absorbance was found at 272 nm. The Linearity was found to be in range of 5 to 40µg/ml. The %RSD for Intraday and Interday precision studies was found to be 0.793 and 0.793 respectively. The % assay was found to be 99.6%±0.05. The average % recovery of ranoalazine was found to be in between 98.5-101.7%. LOD and LOQ was found to be 0.58 µg/ml and 1.75 µg/ml respectively. The results suggest that this method can be employed for routine analysis of Ranolazine in bulk and commercial pharmaceutical formulations.

KEYWORDS

Ranolazine UV Spectrophotometric Method Method Development and Method Validation.

Cite This Article

Patlolla Pravalika, Ankilla Sri Krishna Goud, Narayana Reddy Gari Manasa Reddy, Gopa Tejasri Sathya Durga, Tadikonda Rama Rao, "A NOVEL SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF RANOLAZINE IN BULK DRUG AND IT’S FORMULATION," International Journal of Scientific Research in Engineering and Management, vol. 8, no. 6, Jun 2024. https://doi.org/10.55041/IJSREM35538

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Publication Date

5/5/2024

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Double-Blind Peer Review

Review Rounds: 2

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