A Polyherbal Approach to Burn Wound Healing: Formulation and Evaluation of Cream Containing Chenopodium album, Praecitrullus fistulosus, and Aloe barbadensis

Burn is a destruction of the physical structure of the skin. Burns are classified into four degrees based on depth ranging from superficial to deep tissue damage are first-degree burn, second-degree, third-degree and fourth-degree. The pathophysiology of burn involves inflammatory response mediated by cytokines, increased vascular permeability and edema formation. As conventional burn cream has topical antibiotics silver sulfadiazine are effective but have side-effects such as delayed healing and hypersensitivity, which increase the focus on herbal burn cream as safe alternative. This study focus on the formulation and evaluation of herbal burn cream using Chenopodium album, praecitrullus fistulosus and aloe-vera. Aloe-vera promotes wound healing by collagen synthesis and also has moisturizing property. Chenopodium album have anti-inflammatory, antimicrobial and antioxidant activity and praecitrullus fistulosus promotes healing through tannins. The extract was prepared by ethanol extraction and then incorporated into cream base. The formulated herbal burn cream was found to be safe, stable and effective and serve as a natural alternative to synthetic burn treatment