A Review of Formulation and Evaluation Sustain Release Tablet for the Treatment of Microbial Disease

Garlic (Allium sativum L., Family Liliaceae) is a strong antimicrobial, antioxidant and anti-inflammatory agent. Aged Garlic has more antioxidant and antimicrobial properties compared to fresh garlic. Garlic essential oil is one of the natural antimicrobial Agent which has broad spectrum of inhibition against microbes. Throughout human history, garlic has been widely used. Allin is enzymatically converted to allicin, the main active ingredient in recently damaged garlic. Allicin has also been suggested as a substitute for antibiotics and a way to prevent thrush. Allicin bioavailability is being thoroughly investigated because of its high instability. Garlic powder tablets have been shown to release allicin under simulated gastrointestinal condition, but their quick disintegration has resulted in low allicin levels and less than alliinase protection.