A Review on: Combinatorial Chemistry in Drug Discovery

A Review on: Combinatorial Chemistry in Drug Discovery

Author Name: Ms. Priyanka Gajanan Wagh

Co-author: Mr. Vishal Shivaji Gaikwad

Pratibhatai Pawar College of Pharmacy, Wadala Mahadev.

Abstract:

Several combination methods were developed to create it Focused or diverse chemical libraries with broad linear ranges or macrocyclic chemical molecules: peptides, non-peptides Oligomers, peptidomimetics, small molecules and natural Product-like organic molecules. any combination method Has its own unique high-throughput screening and encoding strategy. In this article we provide a brief overview of it Combinatorial Chemistry in Drug Discovery, with emphasis on In recent years, design, synthesis, Combinatorial library screening and decoding. Example Successful application of combinatorial chemistry in thermal shock Discovery and lead compound optimization are presented. restrictions and The advantages of combinatorial chemistry are also briefly discussed. We are now better able to actually take advantage of Combination technologies for discovery and development Next generation medicines.

Keywords  – Non-peptides, Oligomers, macrocyclic, peptidomimetics