A Review on PREPARATION OF DICLOFENAC SODIUM MATRIX TABLETS

A Review on PREPARATION OF DICLOFENAC SODIUM MATRIX TABLETS

H.S.Chaudhari, R.M.Chaudhari, A.N.Patil, R.B.Lovhare

ABSTRACT

Diclofenac sodium (DS) is a sodium [2(2,6 dichloroanilino) phenyl] acetate-based non steroidal anti-inflammatory and analgesic. It has been used to treat osteoarthritis and rheumatoid arthritisonalong-term, symptomatic basis. The prevention or decrease of negative effects brought on by dosage dumping or excessive plasma drug concentrations. Lower dosage leads to an improvement in patient compliance. Products should be chewed or crushed because doing so can cause toxicity and a loss of the gradual release features of the product. The type of substituents  that make up the polymer, such as their molecular structure or level of substitution, determine how quickly HPMC hydrates. DS was weight using a Denver electronic balance (swiss made), and all of the excipients were properly combined to ensure consistent mixing before being sieved using a 60mesh screen. The funnel method was used to calculate the angle of repose. The IP was used to determine the medication content.

KEYWORDS- osteoarthritis, gradual, viscosity, demonstrate, hydroxypropyl methylcellulose, ionicstrength.