An Efficient synthesis of novel 8,8-dimethyl-2-(4- nitrophenyl)-5-phenyl-5,7,8,9-tetrahydro-6H- [1,3,4]thiadiazolo[2,3-b]quinazolin-6-one catalyzed by Cu(OAc) 2

                To generate a series of thiadiazolo[2,3-b] quinazolin-6-ones, a one-pot, one-step, multicomponent reaction involving dimedone, substituted aromatic aldehydes, and 5-aryl-1,3,4-thiadiazol-2-amines in the presence of Cu(OAc)2 under solvent conditions like ethanol has been devised. This procedure is quick, simple, practical, and eco-friendly. High to exceptional yields, high reaction speeds, avoidance of hazardous organic solvents, simplicity of use, simple catalyst recycling and separation, appropriateness for large-scale synthetic applications, generation of water as green waste, and superior atom economy and the evaluation of  antimicrobial activity

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