ANTIMICROBIAL ACTIVITY OF TELFAIRIA OCCIDETALIS AGAINST SALMONELLA TYPHI AND E.COLI

Aims: The purpose of this research is to determine the antimicrobial activity of Telfairia occidentalis on Salmonella Typhi and E.coli . Study design: The study made use of experimental study design. Place and Duration of Study: The study was carried out at the Department of Microbiology Gombe State University. Methodology: The plant was screened for the presence of phytochemicals and to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the plant extract on the test organism Results: The ethanolic extract of Telfairia occidentalis shows maximum activity against the bacterial isolates with the highest zone of inhibition recorded at 28mm and the least 10m, the MIC and MBC were determined at 12.5mg/ml & 6.25mg/ml and 12.5mg/ml & 12.5mg/ml respectively for both Salmonella typhi and E. coli. Conclusion: Results obtained from this study has shown that ethanolic extracts of the plants T. occidentalis in varying concentrations had antimicrobial activities on almost all the test organisms that were used. This means that constituents of this plant extract may serve as a source of industrial drugs in the treatment of some infections