Azo Prodrug of Meclofenamic Acid: Implications and Applications

Azo Prodrug of Meclofenamic Acid: Implications and Applications

Pallavi sahu, Rajesh Meshram*, Pankaj Masih, Dheeraj Ahirwar, Manisha Masih, Sharang Bali.

Address for correspondence: rmlumina@gmail.com

School of pharmacy, CEC, Bilaspur, 495004.

Abstract: In the ever-evolving field of drug pharmacology and pharmaceuticals, the advancements in biomechanical studies have paved the way for a deeper understanding of drug pharmacokinetics and pharmacodynamics. However, as the demand for novel drug delivery systems grows, there is a pressing need to explore the implications and potential applications of these findings. The present study focuses on the prodrug formation and the release of meclofenamic acid from its azo derivative. The researchers suggest that the release kinetics of the active drug, meclofenamic acid, could follow a power-law dependence on time, which arises from the mechanism of prodrug activation. This model is then used to interpret the measured release of meclofenamic acid from capsules in phosphate buffer saline. The findings indicate that the generated drug profiles could be of critical importance for understanding the prodrug's antimutagenic effect. Furthermore, the study highlights the need to consider not only the early but also the late drug release mechanisms in mathematical models, as these can be essential for understanding the association between physical stimuli and drug efficacy or toxicity.

Keywords: Azo prodrug, Meclofenamic acid, Pharmacokinetics, Pharmacodynamics, Drug delivery