Bioavailability improvement of BCS Class II & III drugs by some formulation strategies: A Review

Bioavailability improvement of BCS Class II & III drugs by some formulation strategies: A Review
*Adarsh Kumar Singh1, Gaurish Narayan Singh2, Pranav Upadhyay3 Rajeev Shukla4
1,2,3,4  Sheat College of Pharmacy Gahani Varanasi UP India

Abstract:

Drug product regulation comes under Biopharmaceutical Classification System (BCS); it is an important tool for categories the drug products into different groups. Bioavailability of drug is major problem of BCS class II & III IV drugs due to is low solubility and low permeability therefore researchers has investigated the various formulation approaches in order to improve bioavailability. BCS class II drugs shows poor bioavailability due to its low solubility and BCS class III drugs also shows poor bioavailability due to its low permeability across the lipid membrane of cells in the body. So that BCS Class III drugs mostly given from parenteral route. This article reviewed some formulation approaches in order to improve bioavailability and which will be better for longer period of time as futuristic approach as well. This review will be able to describe comprised formulation strategies for enhancement of bioavailability.

Keywords: BCS Class II & III, Bioavailability, Permeability, Solubility, Biopharmaceutical.