Biofilm-Forming Clinical Isolates - A Risk Factor for Multidrug Resistance

In conclusion, this study demonstrates a strong positive correlation between biofilm production and multidrug resistance profiles among clinical bacterial isolates. The high prevalence of MDR strains among biofilm-forming Klebsiella spp., Pseudomonas spp., and Staphylococcus spp. underscores the clinical challenge these pathogens present. These findings highlight the need for systematic epidemiological surveillance of biofilm-producing phenotypes in clinical settings and the development of targeted anti-biofilm therapeutic strategies to disrupt the EPS matrix and restore antibiotic efficacy.

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