COMPARATIVE ASSAY STUDY OF DIFFERENT MARKETED BRANDS OF DAPAGLIFLOZIN AND PIOGLITAZONE TABLETS BY USING UV SPECTROPHOTOMETRY

The present study successfully compared three marketed brands each of Dapagliflozin (10 mg) and Pioglitazone (15 mg) tablets by UV spectrophotometry at 223 nm and 234 nm, respectively. The mean assay values obtained were 97.33%, 97.87% and 98.50% for Dapagliflozin, and 96.78%, 97.78% and 98.50% for Pioglitazone, in Brand A, Brand B and Brand C respectively, all of which complied with the pharmacopoeial acceptance limit of 90.0-110.0% of the labelled claim. Brand C consistently exhibited the highest drug content among the three brands studied. The results confirm that UV spectrophotometry is a simple, accurate, precise and economical analytical technique suitable for the routine quality control and comparative brand-to-brand evaluation of Dapagliflozin and Pioglitazone tablets. Further studies employing fully validated methods (linearity, accuracy, precision, LOD, LOQ as per ICH Q2(R1) guidelines) across a larger number of brands are recommended to strengthen these findings.

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