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Stream/Area:
-
Subject:
-
Paper ID:
10.55041/IJSREM56498
Volume:
10 |
2 |
Feb 2026
Pages:
Publication Frequency:
Monthly (12 issues per year)
License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.
Background: Hyaluronic acid (HA) and niacinamide are validated cosmetic actives with distinct mechanisms, yet comprehensive comparisons of their optimized serum formulations are limited. Aims: To design, develop, and comparatively evaluate two serum formulations containing 1% HA (HA-S) and 5% niacinamide (N-S) using Quality-by-Design (QbD) principles. Methods: Pre-formulation screening used a 3×4 factorial design. Optimized formulations underwent physicochemical analysis, in vitro porcine skin permeation (Franz cells), hydration assessment via Corneometer® (n=12 human volunteers), sensory evaluation (n=20 trained panelists), accelerated stability (40°C/75% RH, 6 months), and Preservative Efficacy Testing (USP ). Results: Formulations showed target pH (5.8-6.0) but differed significantly in viscosity (HA-S: 200±15 cP; N-S: 75±10 cP; p
KEYWORDS
Publication Date
10/1/2026
Peer Review Type
Double-Blind Peer Review
Review Rounds: 2
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Conflict of Interest
The authors declare no conflict of interest related to this research work.
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