COMPARATIVE IN-VITRO EVALUATION OF FIVE DIFFERENT BRANDS OF DICYCLOMINE.HCL TABLETS

The objective of current study is comparative in-vitro evaluation of five different brands of dicyclomine.hcl tablets. The chemical qualities of dicyclomine hydrochloride tablets marketed in India were assured and are independent of the drug’s country of origin. The dissolution profile of the different brands of dicyclomine hydrochloride tablets revealed poor drug release. In vitro dissolution studies help in predicting biological drug release pattern in terms of rate and extent of release. No universal dissolution tests has been designed that gives the same rank order for in vitro dissolution and in vivo bioavailability. The present study showed that the weight uniformity, hardness, friability, disintegration time, absolute drug content, melting point, dissolution rate and anticholinergics activity of the five brands were determined using official method as applicable. The five brands passed the uniformity of weight test with the range of 0.351-0.676g, hardness test with range of 4.00- 10 kgF, friability test with range of 0.146-0.268%, absolute drug content a range of 98.82-107.02% and melting point tests and conformed with pharmacopeia specifications. The brands A,B,C and D and E showed appreciable activity against the test organism. All 5 brands of dicyclomine hydrochloride passed their test according to the criteria of Indian pharmacopeia.