Conventional Method for the Synthesis of series of N-phenyl Nicotinamide Analogous Promoted by Iodine

Conventional Method for the Synthesis of series of N-phenyl Nicotinamide Analogous Promoted by Iodine

M.Sai Ganesh1, L. Nagakiran 1, K.D.Prabodh1, Dr.  N. Krishnarao 1*.

 1*.Department of organic chemistry, PRISM PG & DG College (Affiliated to Andhra University), Visakhapatnam, India

ABSTRACT:

In the present study, the conventional process of bioactive synthesis of N-phenyl Nicotinamide analogous. These derivatives (4) can be synthesized from nicotinoylchloride (2) with the different substituted aromatic amines (3) in the presence of I2/K2CO3 ethanol at reflux. The nicotinoylchloride (2) can be prepared by nicotinic acid with thionyl chloride in the presence of MDC at 400C. All desired compounds were evaluated by 1H-NMR and 13CNMR spectroscopy and LCMS. These new N-phenyl Nicotinamide derivatives were examination pharmacological activities in microbial activity. Some of tested compounds exhibited strong activity while the other showed moderate against.

KETWORDS:

Nicotinoylchloride, aromatic amines, I2, N-phenyl Nicotinamide, Antimicrobial activity