Deigned Synthesis of N-(5-(4-methoxyphenyl) thiazol-2-yl) benzamide analgueous Promoted By Imidazoles as a catalyst

An efficient and convenient method has been explained for N-(5-(4-methoxyphenyl) thiazol-2-yl) benzamide derivatives that can be obtained from the reaction of 5-(4-methoxyphenyl) thiophen-2-amine and substituted aromatic carbonyl halides in the presence of Imidazoles and MDC solvent at reflux. 5-(4-methoxyphenyl) thiophen-2-amine can be prepared from 2-bromo-1-(4-methoxyphenyl) ethan-1-one with thiourea in the presence of sodium acetate and acetic acid at 350C. All the compounds were evaluated by advanced spectroscopic data (1H NMR, 13C NMR and LCMS) and the structural determination was evaluated by elemental analysis. Besides to this, all the newly synthesized compounds were examined for their antibacterial activities and antifungal activity by disc diffusion method against the organism of Aspergillus Niger and Candida albicans.