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ArticlePeer ReviewedOpen AccessPlagiarism Passed
Paper ID:IJSREM63169

DESIGN AND DEVELOPMENT OF A FRAMEWORK FOR PHARMACEUTICAL DRUG TO DRUG INTERACTION PREDICTION SYSTEM USING MACHINE LEARNING

Stream/Area:

-

Subject:

-

Paper ID:

IJSREM63169

Volume:

10 |

5 |

May 2026

Pages:

1-3

Publication Frequency:

Monthly (12 issues per year)

DOI
Digital Object Identifier
10.55041/IJSREM63169

License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.

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Authors

BLPJ

Bonthu L P Jyothi

Computer Science & Engineering

BVCITS AMALAPURAM

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PSR

Peruri Sandhya Rani

Computer Science & Engineering

BVCITS AMALAPURAM

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Mentors

ASRSM

A S R S MEGHANA

Computer Science & Engineering

BVCITS AMALAPURAM

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Abstract

Drug–Drug Interactions (DDIs) pose a significant challenge in modern healthcare, often leading to adverse effects, reduced drug efficacy, or unexpected patient reactions. Traditional methods rely heavily on static databases and manual verification, which limits scalability and real-time analysis. This paper proposes a Machine Learning-based Drug–Drug Interaction Prediction System that utilizes Natural Language Processing (NLP) and classification algorithms to predict interactions between drug pairs. The system employs TF-IDF vectorization for feature extraction and models such as Random Forest, Decision Tree, Logistic Regression, and Naive Bayes for prediction. Implemented as a web-based application using Python and Flask, the system provides real-time predictions and improves decision-making for healthcare professionals. Experimental results indicate improved accuracy and efficiency compared to conventional approaches.

KEYWORDS

Key Words: Drug–Drug Interaction Machine Learning Natural Language Processing TF-IDF Random Forest Healthcare Prediction System

Cite This Article

Bonthu L P Jyothi, Peruri Sandhya Rani, A S R S MEGHANA, "DESIGN AND DEVELOPMENT OF A FRAMEWORK FOR PHARMACEUTICAL DRUG TO DRUG INTERACTION PREDICTION SYSTEM USING MACHINE LEARNING," International Journal of Scientific Research in Engineering and Management, vol. 10, no. 5, pp. 1-3, May 2026. https://doi.org/10.55041/IJSREM63169

Full Article/Conclusion

The Drug–Drug Interaction Prediction System helps healthcare professionals quickly identify possible drug interactions. It uses machine learning algorithms like Random Forest, Decision Tree, Logistic Regression, and Naive Bayes along with NLP techniques. TF-IDF is used to convert text data into numerical form for better accuracy. The system includes features like user login, secure data handling, prediction, and admin monitoring. Overall, it provides a reliable and efficient solution for drug interaction prediction.

References

[1] Feixiong Cheng and Zhiyong Zhao, “Machine learning-based prediction of DDIs,” Journal of the American Medical Informatics Association (JAMIA), 2014. [2] Jae Yong Ryu et al., “Deep learning improves DDI prediction,” Proceedings of the National Academy of Sciences (PNAS), 2018. [3] Peng Zhang et al., “Label propagation for DDI prediction,” Scientific Reports, 2015. [4] Andrej Kastrin et al., “Statistical learning for DDIs,” PLOS ONE, 2018. [5] Raziur Ferdousi et al., “Computational DDI prediction,” Journal of Biomedical Informatics (JBI), 2017.

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Publication Date

5/14/2026

Peer Review Type

Double-Blind Peer Review

Review Rounds: 2

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The authors declare no conflict of interest related to this research work.

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