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Stream/Area:
-
Subject:
-
Paper ID:
IJSREM53291
Volume:
9 |
10 |
Oct 2025
Pages:
Publication Frequency:
Monthly (12 issues per year)
License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.
This study aimed to develop, optimize, and evaluate mucoadhesive buccal tablets of Pravastatin Sodium (PVS) using a systematic Design of Experiments (DoE) approach. Pravastatin Sodium, a lipid-lowering agent, suffers from low bioavailability due to extensive first-pass metabolism. A buccal drug delivery system offers an effective way to bypass the first-pass metabolism and improve bioavailability. The study employed Box-Behnken Design (BBD) to optimize formulation parameters like polymer concentrations, excipients, and processing conditions. The tablets were evaluated for various physicochemical parameters, in vitro release, mucoadhesion, and stability. The optimized formulation showed satisfactory drug release, mucoadhesive strength, and stability, making it a promising candidate for improving the therapeutic efficacy of Pravastatin Sodium.
KEYWORDS
Publication Date
10/29/2025
Peer Review Type
Double-Blind Peer Review
Review Rounds: 2
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Conflict of Interest
The authors declare no conflict of interest related to this research work.
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