Development and Evaluation of Menthol based Antacid

Antacids are commonly used self-prescribed medications. It consist of calcium, magnesium and aluminum salts in various combinations. The effect of antacids on the stomach is due to partial neutralization of gastric hydrochloric acid and inhibition of the photolytic enzyme, pepsin. Herbal antacids are also one of the major classes of over the counter drugs used by patient considering its safety. Hence, in present study we attempted to prepare two formulations, one is aluminum hydroxide suspension and second is combination of calcium carbonate and magnesium oxide suspension as well as compares this by marketed formulation through antacid activity using in vitro methods via- acid-Neutralizing capacity and buffering capacity. From the results of present study, it may be concluded that our both formulations possess more antacid potential than marketed formulation.