Development and Evaluation of Nanosponge Contaning Terbinafine Hydrochloride

Healthcare professionals continue to struggle with fungal infections. In this work, the Emulsion Solvent Diffusion Method is used to develop, formulate and assess a nanosponge system loaded with Terbinafine Hydrochloride (TH). The goal of the current study was to increase Terbinafine Hydrochloride’s ability to treat fungal infections by improving medication delivery. Ethyl Cellulose, Polyvinyl Alcohol and Hydroxy Propyl Methyl Cellulose (HPMC) were used as polymers to develop the nanosponges, which were then created using the Emulsion Solvent Diffusion Method. 6 batches of nanosponges were developed, and their compatibility features were evaluated using a variety of characterization techniques, such as Scanning Electron Microscopy, Fourier-Transform Infrared Spectroscopy and particle size analysis. There are bright potential for enhancing antifungal therapy with the creation of Terbinafine Hydrochloride-loaded nanosponges employing the Emulsion Solvent Diffusion approach. The nanosponges increased antifungal efficacy and prolonged drug release point to the possibility of using them as an innovative medication delivery mechanism to treat fungus infections. (