Development of a Bioactive Herbal Nanoparticle Spray for Sweat Control Using Chitosan Nanoparticles and Plant Extracts

. This work designed a bioactive herbal nanoparticle spray for sweat control using chitosan nanoparticles (CS-NPs) loaded with herbal extracts of green tea, tulsi, mint, and lemon peel. The CS-NPs were synthesized through ionic gelation, showed the best properties (120 ± 15 nm size, +35.2 mV zeta potential), and improved stability. The spray formulation is skin-friendly with a pH of 5.03, besides being highly stable and able to exhibit antibacterial activities against Staphylococcus aureus and Corynebacterium. Human trials have shown that sweat production decreases by 30%, nearly as effective as most commercial antiperspirants, but much more compatible with skin. User feedback has indicated highly satisfactory uptake, with almost 85% mentioning reduced sweating and no irritation. Through interaction against CS-NPs with diffuse herbal extracts, there was enhanced bioavailability and efficacy relative to a natural, eco-friendly alternative for hyperhidrosis management. Further studies are suggested for long-term safety and scaling up for market translation.