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Stream/Area:
-
Subject:
-
Paper ID:
IJSREM66707
Volume:
10 |
8 |
Aug 2026
Pages:
1-4
Publication Frequency:
Monthly (12 issues per year)
License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.
Department of Pharmaceutics
Sri Vijay Vidyalaya College of Pharmacy Nallampalli Dharmapuri
Department of Pharmaceutics
Sri Vijay Vidyalaya College of Pharmacy Nallampalli Dharmapuri
Department of Pharmaceutics
Sri Vijay Vidyalaya College of Pharmacy Nallampalli Dharmapuri
Department of Pharmaceutics
Sri Vijay Vidyalaya College of Pharmacy Nallampalli Dharmapuri
Microsponge technology represents a novel drug delivery approach that allows controlled release of active ingredients while minimising skin irritation and improving patient compliance, making it particularly suitable for topical herbal formulations. Mimusops elengi (Bakul), a medicinal plant traditionally used for its anti-inflammatory, antimicrobial, antioxidant and wound-healing properties, contains flowers rich in flavonoids, tannins and saponins with proven therapeutic potential. However, direct topical application of plant extracts is often limited by poor stability, rapid degradation and lack of sustained release. The present study was undertaken to develop and evaluate a microsponge-based gel loaded with Mimusops elengi flower extract in order to achieve controlled release and enhanced skin retention of the active constituents. Microsponges were prepared by the quasi-emulsion solvent diffusion method using Eudragit RS100 as the rate-controlling polymer, and the prepared microsponges were incorporated into a Carbopol 934-based gel base. The formulated batches (MS1-MS4) were evaluated for production yield, particle size, entrapment efficiency, drug content and surface morphology, while the resulting gel formulations were evaluated for pH, viscosity, spreadability, drug content, in vitro drug release and stability. The results demonstrate that Mimusops elengi flower extract can be successfully incorporated into a microsponge drug delivery system to achieve a stable, controlled-release topical gel formulation with potential application in the management of skin disorders.
KEYWORDS
In the present study, Mimusops elengi flower extract loaded microsponges were successfully developed by the quasi-emulsion solvent diffusion method and incorporated into a Carbopol 934-based gel to obtain a stable, controlled-release topical formulation. The formulated microsponge gel exhibited satisfactory physicochemical properties, acceptable drug entrapment and content, and a controlled in vitro drug release profile, indicating its potential as an effective and patient-compliant alternative to conventional topical herbal formulations. The study supports the application of microsponge technology for the delivery of phytoconstituents with otherwise limited topical bioavailability. Further studies involving ex vivo skin permeation, antimicrobial/anti-inflammatory activity evaluation and clinical/user acceptability studies are recommended to further establish the therapeutic potential of the developed formulation.
In the present study, Mimusops elengi flower extract loaded microsponges were successfully developed by the quasi-emulsion solvent diffusion method and incorporated into a Carbopol 934-based gel to obtain a stable, controlled-release topical formulation. The formulated microsponge gel exhibited satisfactory physicochemical properties, acceptable drug entrapment and content, and a controlled in vitro drug release profile, indicating its potential as an effective and patient-compliant alternative to conventional topical herbal formulations. The study supports the application of microsponge technology for the delivery of phytoconstituents with otherwise limited topical bioavailability. Further studies involving ex vivo skin permeation, antimicrobial/anti-inflammatory activity evaluation and clinical/user acceptability studies are recommended to further establish the therapeutic potential of the developed formulation.
Publication Date
8/12/2026
Peer Review Type
Double-Blind Peer Review
Review Rounds: 2
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Conflict of Interest
The authors declare no conflict of interest related to this research work.
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