Loading article...
Loading article...
Stream/Area:
-
Subject:
-
Paper ID:
IJSREM66604
Volume:
10 |
8 |
Aug 2026
Pages:
1-11
Publication Frequency:
Monthly (12 issues per year)
License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.
Pharmacy Practice
KVM College Of Pharmacy
Pharmacy Practice
KVM College Of Pharmacy
Pharmacy Practice
KVM College Of Pharmacy
Chronic kidney disease (CKD) can be described as an advancing condition where there is a reduction in renal function leading to several biochemical alterations in the blood, including electrolytes imbalance, and this increases the chances of acceleration in continuous, gradual decline of illness. Impaired renal tubular function in CKD disrupts the homeostasis of sodium, potassium, calcium, phosphorus, magnesium, and uric acid; this disruption leads to conditions like hyperkalemia, hypocalcemia, hyperphosphatemia, hyperuricemia, and hypermagnesemia [1,3]. The prevalence and severity of these electrolyte disturbances rise as the glomerular filtration rate (GFR) drops, and are strongly associated with comorbidities like diabetes mellitus and hypertension [2]. Electrolyte imbalance in CKD are tied to cardiovascular issues, mineral and bone disorders, nerve and muscle dysfunction, lower quality of life, and advancement towards end-stage renal disease (ESRD)[1,3]. Recent long term studies have shown that ongoing patterns in electrolyte levels - especially persistent hyperkalemia and hyperphosphatemia, may predict adverse renal outcomes and hospitalization risk among pre-dialysis CKD patients[1] Early identification, continuous biochemical monitoring, individualized dietary modification, and appropriate pharmacological management are therefore essential to slowing the progression of the disease and enhancing patient care in CKD patients[2,3].
KEYWORDS
Electrolyte disturbances are common and clinically significant complications of chronic kidney disease. Abnormalities in sodium, potassium, calcium, and phosphorus contribute to cardiovascular morbidity, bone disease, neurological complications, poor quality of life, and accelerated progression to ESRD. Recent studies demonstrate that longitudinal electrolyte temporal pattern provide important prognostic information beyond single laboratory measurements. Early recognition, continuous monitoring, and individualized management of electrolyte abnormalities are essential for improving patient outcomes and delaying dialysis initiation. Comprehensive multidisciplinary care incorporating biochemical, clinical, and psychosocial interventions may substantially improve the overall health and quality of life of CKD patients.
1. Lin CH, Chung MC, Yeh CY, Wu LY, Chen TH, Hung PH, Chung CJ. Electrolyte trajectories in chronic kidney disease primary care: An 11-year follow-up study. Journal of the Formosan Medical Association. 2025:1-7 2. Khan ZA, Khan RA, Najmuddin, Khan AM, Fahad S, Safir SR. Electrolyte imbalances in kidney disease: Hyponatremia hyperkalemia and hypocalcemia. Journal of Population Therapeutics and Clinical Pharmacology. 2022;29 (02):623–628. 3. Sharma S, Kalra D, Rashid I, Mehta S, Maity MK, Wazir K, Gupta S, Ansari SA, Alruqi OS, Khan R, et al. Assessment of health-related quality of life in chronic kidney disease patients: A hospital-based cross-sectional study. Medicina. 2023; 59: 1788. 4. Brookes EM, Snider J, Hart GK, et al. Serum potassium abnormalities in chronic kidney disease: prevalence, patient characteristics and clinical outcomes. Intern Med J 2021; 51: 1906–18. 5. Tsao HM, Lai TS, Chou YH, Lin SL, Chen YM. Predialysis trajectories of estimated GFR and concurrent trends of chronic kidney disease-relevant biomarkers. Ther Adv Chronic Dis. 2023; 14: 1-12. 6. Andrassy, K.M. Comments on ‘KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease’. Kidney Int. 2013, 84, 622–623. 7. Lee WC, Kwon YE, Han IM, Kim Y, Kim DK, Joo KW, et al. Hyponatremia is associated with fluid imbalance and adverse renal outcome in chronic kidney disease patients treated with diuretics.2016;14;6:36817 8. Cole NI, Suckling RJ, Desilva V, He FJ, MacGregor GA, Swift PA. Serum sodium concentration and the progression of established chronic kidney disease. J Nephrol. 2019; 32(2):259-264. 9. Kurtz I, Maher T, Hulter HN, Schambelan M, Sebastian A: Effect of diet on plasma acid-base composition in normal humans. Kidney Int 1983; 24: 670–680. 10. Fisch C. Relation of electrolyte disturbances to cardiac arrhythmias. Circulation. 1973; 47(2):408-419.
Publication Date
8/8/2026
Peer Review Type
Double-Blind Peer Review
Review Rounds: 2
Documents
Article Views
0
Total views since publication
PDF Downloads
3
Total downloads since publication
Geographic Reach
5
Digital Preservation: This article is permanently archived on Zenodo and complies with all data preservation standards across major indexing platforms.
Plagiarism Screening
This manuscript has been checked for plagiarism using TurnitinPlagiarismChecker software.
Conflict of Interest
The authors declare no conflict of interest related to this research work.
Funding Information
No funding information available for this research.
Related research in the same subject area
Loading similar articles...