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Stream/Area:
-
Subject:
-
Paper ID:
IJSREM67120
Volume:
10 |
9 |
Sep 2026
Pages:
1-7
Publication Frequency:
Monthly (12 issues per year)
License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.
Microbiology
Mahatma Gandhi Arts, Science and Late N. P. Commerce College, Armori, India
Microbiology
Sardar Patel Mahavidyalaya, Chandrapur, India
In the battle against S. aureus infections and the growing crisis of antibiotic resistance, health departments are facing challenges and exploring alternative treatments such as antivirulence drugs. Staphyloxanthin (STX), protects S. aureus against neutrophil-mediated eradication by providing antioxidant properties, has emerged as a novel target for antivirulence therapy. Stripping off this pivotal pigment from STX-producing S. aureus (SPSA) strains is a promising approach. Plant-derived products, specifically Essential Oils (EOs) natural antioxidants are complex mixtures of secondary metabolites derived from aromatic plants and offer a rational strategy to tackle the complexities associated with SPSA infections presenting an intriguing avenue for therapy.This study correlates antioxidant activity with sensitivity patterns of 16 EOs employed in the battle against SPSA. Clove EO (98.9%) exhibited exceptional antioxidant activity, closely followed by cinnamon (98.06%), thyme (92.79%), peppermint (80.43%), and tea tree (77.22%) EOs. Tulsi, eucalyptus, and ginger EO had moderate activity, while lemon, orange, lemongrass, linseed, castor, mustard, sunflower, and sesame exhibited poor antioxidant activity. Statistical analysis was used to assess their sensitivity patterns. This study demonstrates a significant linear correlation (p < 0.05) between the antioxidant activity and sensitivity patterns of EOs, suggesting that EOs with strong antioxidant properties may effectively inhibit SPSA isolates. These results highlight the potential of EOs as effective agents in combatting SPSA infections and aiding targeted therapies to counter S. aureus infections. By harnessing the natural antioxidant properties of EOs, it may develop innovative approaches to address the challenges posed by S. aureus infections and the antibiotic resistance crisis.
KEYWORDS
The general observation indicates that EOs can be utilized as therapeutic agents in the treatment of S. aureus infections especially SPSA-causing strains on the basis of their antioxidant property, they suppress the formation of STX, stimulate immune response and promote clinical outcome. The insights can be useful in considering the application of EO as alternative treatment of multidrug-resistant strains, as such approach is natural and may be rather effective. Nevertheless, additional in vivo and clinical studies are required to confirm the effectiveness, safety, and the potential of EOs as supplementary treatment to conventional antibiotics. Also, in future studies, emphasis must be made on the identification of particular constituents and action mechanisms of synergistic interactions between the various constituents in EOs that are involved in their antimicrobial activity against SPSA isolates.
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Publication Date
9/5/2026
Peer Review Type
Double-Blind Peer Review
Review Rounds: 2
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