Evaluation of the Anti-Asthmatic and Antihistaminic Properties of Urtica dioica Leaves

This study aims to evaluate the anti-asthmatic and antihistaminic activity of the leaves of Urtica dioica. Phytochemical analysis confirmed the presence of alkaloids, flavonoids, steroids, tannins, saponins, phytosterols, and glycosides. Acute toxicity studies established the safety of the extract at 5000 mg/kg. In vitro antihistaminic activity using isolated guinea pig ileum preparation showed significant inhibition of histamine-induced contraction. In vivo bronchospasm protection was also evident through increased preconvulsion time. The results confirm traditional claims and offer potential for development as a plant-based therapy for asthma and allergic conditions.