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Paper ID:IJSREM65534

Explainable AI (XAI) for Early Detection of Diabetic Retinopathy

Stream/Area:

-

Subject:

-

Paper ID:

IJSREM65534

Volume:

10 |

6 |

Jun 2026

Pages:

1--

Publication Frequency:

Monthly (12 issues per year)

DOI
Digital Object Identifier
10.55041/IJSREM65534

License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.

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Authors

MAMS

Mohd Afsar Mainuddin Shaikh

Department of Artificial Intelligence and Data Science

Anjuman-I-Islam Abdul Razzak Kalsekar Polytechnic Campus

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Mentors

PAK

Prof. Ali Karim

Department of Artificial Intelligence and Data Science

Anjuman-I-Islam Abdul Razzak Kalsekar Polytechnic Campus

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Abstract

Diabetic retinopathy (DR) is a leading cause of blindness, yet outcomes improve dramatically when the condition is caught early. Deep learning models now rival specialists in DR screening, but their “black box” nature continues to worry clinicians. We propose an explainable AI framework that pairs a convolutional neural network with several post hoc explanation techniques, enabling the model to both detect DR in fundus photographs and reveal which retinal regions drive its predictions. The system builds on a transfer learned ResNet 50 backbone and combines Grad CAM, LIME, and SHAP to offer visual, local, and Shapley value explanations. Training and validation used the EyePACS dataset (35 126 images); a separate Messidor 2 set served as the independent test bed. Overall accuracy reached 96.5 %, with 94.8 % sensitivity and 97.3 % specificity. Generated explanation maps consistently highlighted microaneurysms, exudates, and haemorrhages. A small reader study with three ophthalmologists confirmed that the explanations significantly boosted diagnostic confidence and trust. The framework shows that high performance and genuine interpretability can go hand in hand, bringing us closer to clinically deployable DR screening.

KEYWORDS

Explainable AI Diabetic Retinopathy Deep Learning Grad CAM Fundus Images Early Detection.

Cite This Article

Mohd Afsar Mainuddin Shaikh, Prof. Ali Karim, "Explainable AI (XAI) for Early Detection of Diabetic Retinopathy," International Journal of Scientific Research in Engineering and Management, vol. 10, no. 6, pp. 1--, Jun 2026. https://doi.org/10.55041/IJSREM65534

Full Article/Conclusion

     We have presented an end‑to‑end XAI framework for detecting diabetic retinopathy that combines solid classification performance with multimodal, human‑readable explanations. The complementary nature of Grad‑CAM, LIME, and SHAP gives clinicians a fuller picture of model reasoning, fosters trust, and helps flag potential errors. In the future, we plan to extend the system to video‑based OCT‑angiography and to incorporate concept‑based explanations grounded in medical lesion ontologies. Prospective clinical trials are on the horizon to test the impact in real screening workflows.

References

1. Gulshan, V., Peng, L., Coram, M., Stumpe, M.C., Wu, D., Narayanaswamy, A., Venugopalan, S., Widner, K., Madams, T., Cuadros, J., Kim, R., Raman, R., Nelson, P.C., Mega, J.L., Webster, D.R.: Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs. JAMA 316(22) (2016) 2402–2410 2. Gargeya, R., Leng, T.: Automated Identification of Diabetic Retinopathy Using Deep Learning. Ophthalmology 124(7) (2017) 962–969 3. Quellec, G., Charrière, K., Boudi, Y., Cochener, B., Lamard, M.: Deep Image Mining for Diabetic Retinopathy Screening. Medical Image Analysis 39 (2017) 178–193   4. Selvaraju, R.R., Cogswell, M., Das, A., Vedantam, R., Parikh, D., Batra, D.: Grad‑CAM: Visual Explanations from Deep Networks via Gradient‑Based Localization. International Journal of Computer Vision 128(2) (2020) 336–359   5. Ribeiro, M.T., Singh, S., Guestrin, C.: “Why Should I Trust You?”: Explaining the Predictions of Any Classifier. In: Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining (KDD), San Francisco, CA, USA (2016) 1135–1144

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Publication Date

6/26/2026

Peer Review Type

Double-Blind Peer Review

Review Rounds: 2

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