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Stream/Area:
-
Subject:
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Paper ID:
IJSREM66691
Volume:
10 |
8 |
Aug 2026
Pages:
1-7
Publication Frequency:
Monthly (12 issues per year)
License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.
Department of Pharmaceutics
Sri Vijay Vidyalaya College of Pharmacy, Nallampalli, Dharmapuri
Department of Pharmaceutics
Sri Vijay Vidyalaya College of Pharmacy, Nallampalli, Dharmapuri
Department of Pharmaceutics
Sri Vijay Vidyalaya College of Pharmacy, Nallampalli, Dharmapuri
Department of Pharmaceutics
Sri Vijay Vidyalaya College of Pharmacy, Nallampalli, Dharmapuri
Free radicals contribute to aging and chronic diseases such as cardiovascular disorder and cancer, promoting interest in safer alternatives to synthetic antioxidants like BHA and BHT, whose long-term use raises health concerns. This study formulated and evaluated a natural antioxidant preparation combining amla (Emblica officinalis) and spinach (Spinacia oleracea), two accessible plants with rich, complementary bioactive profiles. Amla is a well-documented source of vitamin C, tannins and polyphenols, including gallic acid, ellagic acid and emblicanins A and B, while spinach contributes flavonoids, carotenoids, chlorophyll compounds, and vitamin E, together enabling antioxidant activity across both water-soluble and fat-soluble environments. Extracts were prepared from each plant using a suitable solvent and formulated individually and in combination for comparative evaluation. Preliminary phytochemical screening confirmed the presence of these bioactive compounds, and total phenolic and flavonoid content was quantified using a UV spectrophotometer. Antioxidant potential was assessed via the FRAP assay, with ascorbic acid used as the reference standard. Results showed that the combined amla-spinach formulation exhibited greater antioxidant activity than either extract alone, suggesting a synergistic interaction, and the formulation demonstrated good stability under the tested conditions.
KEYWORDS
The formulated herbal lozenges exhibited antioxidant activity, indicating their ability to neutralise free radicals and reduce oxidative stress. This antioxidant effect may be attributed to the presence of polyphenols, flavonoids, tannins, carotenoids and vitamin C in the herbal extracts, which may help protect cells from oxidative damage and support overall cellular health. Thus, the developed herbal lozenges show promising potential as a natural antioxidant formulation.
[1] Darade Ashwini D. Medicated lozenges: an updated review. World J Pharm Sci 2021; 9(2): 117-124. [2] Vidya Marwal, Neha Sodiyal, S.M. Patil. Formulation and evaluation of herbal lozenges. International Journal of Novel Research and Development, ISSN: 2456-4184, Vol 8, Issue 6. [3] Stephen O. Majekodunmi. A review on lozenges. American Journal of Medicine and Medical Sciences 2015; 5(2): 99-104. [4] Swetha Yoganandan, Gururaj S. Kulkarni, Padmaa M. Paarakh, Surinder Kaur, A. Muthukumar. Comparative analysis of herbal and non-herbal lozenges. International Journal of Research in Pharmacy and Allied Sciences (IJRPAS) 2024; 3(4): 51-62. [5] Kirti C. Godse, V.Y. Lokhande, Komal Shinde, Prachi Pawar. Formulation and evaluation of polyherbal lozenges for the treatment of sore throat. World Journal of Pharmaceutical and Life Sciences 2025; 11: 332-339. [6] Arvapalli S, Vaishnavi A, Rishika PS, Unnisa SJ, Karunakar B, Sharma JVC. Design, characterization and evaluation of hard candy lozenges of Raphanus sativus leaf extract. International Journal of Biology, Pharmacy and Allied Sciences 2022; 11(2): 740-749. [7] Yahaya Vahaya Makera, Akash Kumar, Vinayak Dasharath Gaikwad, Dinesh Upadhyay, Subharanshu Panda. Preparation and evaluation of polyherbal lozenges for the treatment of cough. World Journal of Pharmaceutical Science and Research 2026; 5: 967-974. [8] Piyush Chaudary. Pre-formulation studies for ayurveda drugs: a review. ISSN: 2230-8407, 2019; 10(3). [9] Saurav Yadav, Ravikant, Satyendra Singh, Pragati Khare, Km. Deeksha. Formulation and evaluation of herbal lozenges containing Glycyrrhiza glabra, Zingiber officinale and Ocimum sanctum for throat disorder. TMP Universal Journal of Advances in Pharmaceutical Sciences 2026; 2: 111-116. [10] Saurabh Kumar, Himanshi Rathur, Sayantan Mukhopadhyay. Formulation and evaluation of herbal lozenges of vasaka leaf for the treatment of sore throat. Archives of Current Research International 25(6): 229-237. [11] Elmira Bajelan, Mohammad Kamali-Nejad, Seyed Mohsen Foroutan, Hiam Albasha. Formulation and physicochemical evaluation of lozenge tablets containing Salvia officinalis. Journal of Young Pharmacists 2014; 6(1): 35-38. [12] Amarowicz R, Pegg RB, Rahimi-Moghaddam P, Barl B, Weil JA. Free-radical scavenging capacity and antioxidant activity of selected plant species from the Canadian prairies. Food Chemistry 2004; 84: 551-562.
Publication Date
8/12/2026
Peer Review Type
Double-Blind Peer Review
Review Rounds: 2
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