FORMULATION AND EVALUATION OF LOCAL ANESTHETIC GEL FROM DATURA STRAMONIUM

Datura stramonium is a wild plant having various medicinal and pharmacological properties and these properties exploited for cancer, rheumatism, ear pain, headache, wound, burn, stress, depression, insomnia, asthma, boils and inflammation. Datura stramonium, exhibits pharmacological effect and prepared as herbal or botanical drugs by pharmaceutical industries for many diseases. Wound healing is the complex which requires proper healing from both internal and external. The development of the anti-inflammatory, antimicrobial gel aims to enhance better recovery of the wound and avoid any infection, especially during the postoperative phase, where there is lots of medications prescribed which suppress immune system, making wound more prone to the microbial attack and resulting in late recovery of the wound. The main component of the plant is alkaloid, which shows the antimicrobial, anesthetic. anti-inflammatory, cytotoxic and analgesic characteristic which accelerate the wound healing process and prevent microbial infestations. The findings suggest that the datura -based gel not only offers a natural alternative to synthetic antifungal agents but also presents a promising option for treating fungal infection. The purpose of current study concludes with recommendations for further research into the gel’s formulation stability and potential application in clinical setting, emphasizing the importance of exploring herbal remedies in modern medicine.