Formulation and Evaluation of Paracetamol Tablet by Using Combination of Caffeine and Aceclofenac

Formulation and Evaluation of Paracetamol Tablet by Using Combination of Caffeine and Aceclofenac

Ms. Rohini More *1, Ms. Suchita Gadekar*2, Mr. Shravan Somani*3, Ms. Manisha Ghavte*4,

*1 Student, Pratibhatai  Pawar College Of Pharmacy, Shrirampur *2,*3, 4, Asst. Professor, Pratibhatai Pawar College Of Pharmacy, Shrirampur, Maharashtra

Corresponding Author: Ms. Rohini More*1

Abstract

The aim of this study was to develop an effective pharmaceutical formulation of paracetamol tablets enriched with the combination of caffeine and aceclofenac. Paracetamol, a widely used analgesic and antipyretic drug, faces challenges in achieving optimal pain relief and improving therapeutic efficacy. Caffeine is well known for its adjunctive role in analgesic preparations, and aceclofenac, a potent nonsteroidal anti-inflammatory drug (NSAID), was selected as a potential enhancer of synergy with acetaminophen. The formulation process includes the selection of appropriate excipients to ensure the stability, bioavailability and compatibility of the active ingredients. Different ratios of paracetamol, caffeine, and aceclofenac were studied to achieve the desired pharmacokinetic profile and therapeutic effect. Tablets are prepared using conventional pharmaceutical techniques and tested for various parameters including physical properties, dissolution profile, drug content uniformity and stability. Preliminary results suggest that the combination of caffeine, aceclofenac, and acetaminophen increases analgesic efficacy and may accelerate onset of action. Furthermore, these tablets exhibited satisfactory physical properties and dissolution behavior, indicating their potential to effectively treat pain. Further studies are needed to evaluate the pharmacokinetic parameters, therapeutic efficacy, and safety of the developed formulations through preclinical and clinical studies.

 Keywords Analgesic, Antipyretic Activity, Anti-Inflammatory Activity