Formulation and Optimization of Betahistidine Microspheres

Betahistidine is an active histamine analog primarily used in the treatment of vertigo, tinnitus, and Meniere’s disease—conditions related to vestibular disorders and inner ear dysfunction. However, Betahistidine’s clinical efficacy is hindered by its short half-life, rapid clearance, and limited oral bioavailability. Polymeric microspheres, especially those made from biodegradable materials such as Poly(lactic-co-glycolic acid) (PLGA) and Chitosan, have shown considerable potential for controlled drug release. The current research work focused on preparation and optimization of Betshistidine microspheres which can be scaled up and used commercially in future.