FORMULATION & EVALUATION OF MOUTH DISSOLVING GRANULE TO TREAT MOUTH ULCER

Mouth ulcers are common oral lesions that cause pain, inflammation, and difficulty in eating and speaking. Conventional treatments such as gels and ointments often show poor patient compliance due to unpleasant taste and difficulty in application. The present study aims to formulate and evaluate mouth dissolving granules for the effective management of mouth ulcers. Mouth dissolving granules are designed to rapidly dissolve in the oral cavity without the need for water, providing faster onset of action and improved patient convenience. In this formulation, suitable active pharmaceutical ingredients along with excipients such as superdisintegrants, sweeteners, flavoring agents, and granulating agents were selected to enhance palatability and rapid dissolution. The granules were prepared using the wet granulation method and evaluated for various physicochemical parameters including particle size, angle of repose, bulk density, tapped density, Carr’s index, Hausner ratio, drug content, and in-vitro drug release. Additionally, parameters such as taste, mouth dissolving time, and stability studies were also assessed. The results indicated that the prepared mouth dissolving granules exhibited good flow properties, rapid disintegration in the oral cavity, and satisfactory drug release profile. Therefore, mouth dissolving granules can be considered a promising dosage form for the effective and convenient treatment of mouth ulcers, improving patient compliance and therapeutic effectiveness.