GENOMIC VIEW ON EPILEPSY AND AUTISM CANDIDATE GENES

The most frequently linked behavioural and neurological disorders to epilepsy are common complex disorders. Numerous disease-associated genes were discovered as a result of extensive parallel sequencing of individual or cohort genomes and exomes. Here, we evaluate the potential genes for epilepsy with an emphasis on exome and gene panel data. The findings demonstrate that, along with the analysis of genes expressed in the brain and the post synaptic proteome. Candidate genes for non-metabolic epilepsies and autism are frequently AT-rich, and Genes implicated in synaptic processes and developmental brain diseases typically have large transcript sizes and local AT-richness. These findings suggest that essential candidate genes for epilepsy and autism are preferentially located in late-replicating, GC-poor chromosomal regions (isochores). These findings suggest that the genetic changes causing various brain illnesses are restricted to responsive chromatin regions containing important genes for the brain. These findings suggest that essential candidate genes for epilepsy and autism are preferentially located in late-replicating, GC-poor chromosomal regions (isochores). These findings suggest that the genetic changes causing various brain illnesses are restricted to responsive chromatin regions containing genes essential for the proper functioning of the brain.