In Silico Phylogenetic Study of the Human Tp53 Gene: Insights into Evolutionary Dynamics

In Silico Phylogenetic Study of the Human Tp53 Gene: Insights into Evolutionary Dynamics

Akhil Kumar Pigili1, Anil Kumar Babu Katika2

1Department of Bioinformatics, Sri Venkateswara institute of medical sciences, Tirupati, India

2Department of Biotechnology, Central Tribal University Of Andhra Pradesh, Vizianagaram, India

The tumour suppressor protein p53, sometimes known as the "protector of the genome," is widely recognised for its crucial function in averting cancer through the regulation of DNA repair, disruption of the cell cycle, and programmed cell death known as apoptosis. Recent research has shown that p53 plays a more complex role in genomic equilibrium than its conventional roles. The Tp53 gene's evolutionary linkages are examined in this work while evolutionary studies are crucial to contemporary scientific research. Studies on evolution provide links that are useful for current study. The Homo sapiens tumour protein Tp53 transcript variant-1 mRNA FASTA sequence used in this work was obtained from the NCBI, after the Multiple Sequence Alignment using UPGMA and MEGA were used to conduct evolutionary experiments with other species. Consequently, this research. Thus, this work will aid current biological research in developing and comprehending the evolutionary dynamics and pathways of the Tp53 gene in Clinical Research.

Keywords: p53, tumour suppressor gene, phylogenetics, evolutionary analysis, sequence alignment, BLAST