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Stream/Area:
-
Subject:
-
Paper ID:
IJSREM66666
Volume:
10 |
8 |
Aug 2026
Pages:
1-4
Publication Frequency:
Monthly (12 issues per year)
License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.
Department of Pharmacology
Sri Vijay Vidyalaya College of Pharmacy, Nallampalli, Dharmapuri
Department of Pharmacology
Sri Vijay Vidyalaya College of Pharmacy, Nallampalli, Dharmapuri
Department of Pharmacology
Sri Vijay Vidyalaya College of Pharmacy, Nallampalli, Dharmapuri
Department of Pharmacology
Sri Vijay Vidyalaya College of Pharmacy, Nallampalli, Dharmapuri
Tectona grandis Linn. f. (Lamiaceae), commonly known as teak, is traditionally used in folk and Ayurvedic medicine as an astringent and anti-inflammatory agent. The present study was undertaken to evaluate the in vitro anti-inflammatory activity of the petroleum ether extract of Tectona grandis bark, obtained by successive Soxhlet extraction, using the protein (albumin) denaturation inhibition assay. Preliminary phytochemical screening of the petroleum ether extract revealed the presence of steroids, terpenoids, quinones, glycosides and fixed oils, while polar constituents such as flavonoids, tannins and saponins were largely absent. The extract exhibited concentration-dependent inhibition of bovine serum albumin denaturation over the range of 200–1000 µg/mL, with percentage inhibition increasing from 12.88 ± 0.17% to 64.42 ± 0.84%, compared with 18.97 ± 0.09% to 94.85 ± 0.45% for the standard drug diclofenac sodium at equivalent concentrations. Although the extract showed lower potency than the standard at every concentration tested, the clear dose-dependent trend confirms genuine anti-inflammatory potential, which may be attributed to the non-polar phytoconstituents (steroids, terpenoids and quinones) detected in the extract. These findings provide preliminary in vitro evidence supporting the traditional use of Tectona grandis bark in inflammatory conditions and warrant further investigation through membrane-stabilisation assays, in vivo models and bioactivity-guided isolation of the responsible constituents.
KEYWORDS
The petroleum ether extract of Tectona grandis bark exhibited concentration-dependent in vitro anti-inflammatory activity, as evidenced by inhibition of bovine serum albumin denaturation ranging from 12.88% to 64.42% over 200–1000 µg/mL. Although less potent than the standard diclofenac sodium at all tested concentrations, the consistent dose-response relationship confirms genuine anti-inflammatory potential in the extract, likely mediated by its steroid, terpenoid and quinone constituents. These findings lend scientific support to the traditional use of teak bark in inflammatory conditions and warrant further studies — including membrane-stabilisation assays, in vivo models, and bioactivity-guided isolation — to fully characterise the responsible constituents and mechanism of action.
[1] Bhangale J, Acharya S, Bhagat S. Antinociceptive and anti-inflammatory activity of aqueous bark extract of Tectona grandis Linn. Indian J Pharmacol. 2010. [2] Han X, et al. Antioxidant, anti-inflammatory and antidiabetic activities of methanolic extract, petroleum ether and ethyl acetate fractions of Tectona grandis. J Ethnopharmacol. 2023. [3] Jaybhaye D, et al. Anti-asthmatic and anticholinergic activity of ethanolic bark extract of Tectona grandis. Int J Pharm Sci. 2020. [4] Singh N, Kaushal K. Pharmacological and phytochemical profile of Tectona grandis Linn (Verbenaceae) – A comprehensive review. Afr J Bio Sci. 2024;6(13). [5] Parawansah, et al. Comprehensive evaluation of Tectona grandis L.f.: integrated in vitro and in silico analysis of steroid 5α-reductase inhibition and anti-inflammatory properties. ACS Omega. 2025. [6] Ghosh A, et al. Antidiabetic activity of Tectona grandis leaf extract in streptozotocin-induced diabetic rats. 2011. [7] Patil S, et al. Hepatoprotective activity of aqueous and alcoholic extracts of Tectona grandis. 2012. [8] Sharma R, et al. Antifungal activity of bark and leaf extracts of Tectona grandis. 2014. [9] Chaudhary P, et al. Phytochemical profiling of Tectona grandis leaves using HPLC and GC–MS. 2021. [10] Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. 1935.
Publication Date
8/11/2026
Peer Review Type
Double-Blind Peer Review
Review Rounds: 2
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The authors declare no conflict of interest related to this research work.
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