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Stream/Area:
-
Subject:
-
Paper ID:
10.55041/IJSREM.ISTCESD055
Volume:
10 |
9 |
Sep 2026
Pages:
1-3
Publication Frequency:
Monthly (12 issues per year)
License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.
Biology
Shivaji Mahavidyalaya, Udgir, Latur
Microbial metabolites—classified broadly into primary and secondary metabolic products—represent an essential biological foundation for bio manufacturing across pharmaceuticals, agriculture, food, and environmental remediation. Primary metabolites are directly tied to cell growth and central carbon metabolism, whereas secondary metabolites function as specialized ecological adaptations that yield high-value bioactive molecules. This comprehensive review synthesizes the classification, biosynthetic architecture, strain engineering strategies, industrial fermentation workflows, and cross-sectoral applications of microbial metabolites. In addition, comparative yield profiles, metabolic dynamics, and economic trajectory models are provided to frame future directions in synthetic biology and metabolic engineering.
KEYWORDS
Despite high specificity and biodegradability, industrial metabolite biomanufacturing faces key scaling bottlenecks: · Upstream Costs: High energy inputs required for continuous aeration, agitation, and thermal control in large-scale fermenters (>100,000 L). · Downstream Recovery: Complex solid-liquid separation, liquid-liquid extraction, and chromatography steps often account for 50%–70% of total production costs. · Waste Valorization: Shifting toward circular bioeconomy models by utilizing agricultural residues (e.g., lignocellulosic biomass, molasses) as low-cost fermentation substrates.
Martinelli, F., & Thiele, I. (2024). Microbial metabolism marvels: a comprehensive review of microbial drug transformation capabilities. Gut Microbes, 16(1), Article 2387400. https://doi.org/10.1080/19490976.2024.2387400 Verma, N., Mishra, D., Pandey, A. P., & Gaur, R. S. (Eds.). (2026). Industrial Applications of Microbial Secondary Metabolites: A Modern Approach. CRC Press. https://doi.org/10.1201/9781003408833
Publication Date
9/29/2026
Peer Review Type
Double-Blind Peer Review
Review Rounds: 2
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The authors declare no conflict of interest related to this research work.
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