Intensely Pleasurable Responses to Effect of Silence Correlate with Neuro Transmitters Activity in Three Brain Distinct Region Implicated in Reward and Emotion on Swiss Albino Mice

Intensely Pleasurable Responses to Effect of Silence Correlate with Neuro Transmitters Activity in Three Brain Distinct Region Implicated in Reward and Emotion on Swiss Albino Mice

Manikannan Vishnupriya, Uthirakumar Devaraj, Vigil Anbiah, Saiful Alom Siddique,

Elumalai Balamurugan*

Department of Biochemistry & Biotechnology Faculty of Science Annamalai University

Abstract

Recent interests in difficult effects of silence on rodents arise from health concerns. Silence/anechoic effect are the sound produced below audible frequency range. Production of acoustic sound can be found ubiquitously on the planet. During the 1970´s anchor was a fairly admired topic, within the scientific community. In spite of the loss of attention over the years, recently it has been gaining significance. In order to study the impact of silence on behavior, physiology and biochemical properties of mice. Animals will be kept in a soundproof chamber (90 days) and will also be exposed to a different range of audible sound. The activity of the animals will be monitored by video tracking and neurotransmitter levels. Monitoring includes conductance of behavioral test open field test and Morris Water Maze test. Quantitative determinations of DA, 5-HT, NE and GABA concentrations in three distinct brain regions (auditory cortex, hippocampus, and amygdala) were determined by the spectrofluorimetric method. This study helps to understand the importance of hearing on behavior and to develop strategies while treating anxiety and other mood disorders where the environment plays an influential role.

Keywords: Acoustic, sound proof chamber, neurotransmitter, anxiety, learning.