Liposomal Drug Delivery: A Promising Approach for Targeted and Sustained Therapy
Archana Garudkar*1, Prof. Randhawan B.B 2, Dhanashri Avhad3, Aarati Shinde4, Arya Shaligram5 , Shravan Yadav6, Nusratfatema Shaikh7, Adesh Zende8
Students1,3,4,5,6,7,8 Assi. Professor2
Arihant College of Pharmacy, Kedgaon, Ahilyanagar – 414005.
Abstract:
Liposomes are thought to be a promising and adaptable form of drug delivery. Site-targeting, sustained or controlled release, protection of drugs from degradation and clearance, superior therapeutic effects, and fewer toxic side effects are some of the better qualities liposomes have over conventional drug delivery systems. Self-generated bilayer lipid hydrations were used to search for lipids or liposomes. The development of potent medications to enhance treatment has been greatly aided by the liposome drug delivery system. Liposome formulations have recently been shown to reduce symptoms and improve conservation at the target site. Cosmetic formulations also make use of liposomes. Biological, chemical, and physical characteristics are used to characterize liposomes. The unique binding characteristics of agglutinating liposomes with target cells, including tumor cells and particular molecules in the body, are recent advancements in this field. Liposome-encapsulated drug candidates have been studied for their longer duration of therapeutic effect and decreased toxicity. Various academic and industrial research groups have established the liposomal encapsulation of hydrophilic and hydrophobic small molecule therapeutics and other large molecule biologics. As of right now, there are a growing number of liposomal-based treatments that have received FDA approval and are also undergoing clinical trials. These treatments have a variety of uses in antiviral, antibacterial, and anticancer treatments. Recent developments have looked into improving the liposomal-based drug delivery system with a more repeatable preparation method. The excipients of liposomal formulations used in numerous novel studies, the most recent methods for preparing liposomes, and the administration routes utilized to deliver liposomes to specific disease areas are the main topics of this review.
Keywords: liposomes, drug delivery system, recent approaches, polymers.
