Nanoparticle-Based Gel Delivery of Suzetrigine for Enhanced Pain Management

The present thesis organized a suzetrigine nanoparticle-based gel project into full academic format while preserving the uploaded Result and Discussion section as the core experimental chapter. The combined evidence shows that suzetrigine could be assessed analytically at 250 nm that the drug remained compatible with the main polymeric system on FTIR and DSC interpretation, and that physically acceptable gels with nanosized characteristics could be prepared. A second consideration is the relationship between material selection and patient-facing performance. A semisolid system can appear simple, but its final behavior depends on dispersion quality, polymer hydration, pH control, viscosity, release rate, and storage stability. When these factors are considered together, the dosage form becomes a structured platform for controlled delivery rather than a simple mixture of drug and excipients. The updated thesis presents a coherent project that begins with a current pain-management problem and ends with practical formulation recommendations.

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