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ArticlePeer ReviewedOpen AccessPlagiarism Passed
Paper ID:IJSREM41088

Navigating the Double- Edged Sword of Diclofenac: Pain Relief and Associated Cardiovascular Safety

Stream/Area:

-

Subject:

-

Paper ID:

IJSREM41088

Volume:

9 |

1 |

Jan 2025

Pages:

Publication Frequency:

Monthly (12 issues per year)

DOI
Digital Object Identifier
10.55041/IJSREM41088

License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.

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Authors

JV

J. Vanitha

T

Thara

RD

R.Sai Deekshith

K

K.Sravani

D

Dr.D.Nagaswetha

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Abstract

Diclofenac sodium (DFS) is a widely prescribed nonsteroidal anti-inflammatory drug (NSAID) effective in managing pain and inflammation in patients with arthritis and musculoskeletal conditions. While DFS is known for its rapid analgesic effects and broad therapeutic indications, it also poses significant cardiovascular (CV) safety concerns. Research highlights that prolonged or high-dose use of diclofenac increases the risk of myocardial infarction, stroke, and thrombotic events. Despite clinical guidelines discouraging its use in patients with heart conditions, a large percentage of individuals continue its use after hospital discharge. This review explores the dual nature of diclofenac’s benefits for pain relief and its associated cardiovascular risks, discussing pharmacokinetics, therapeutic indications, adverse effects, and regulatory recommendations.

KEYWORDS

Diclofenac Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Cardiovascular Risk Pain Relief COX-1 and COX-2 Inhibition Myocardial Infarction Prostaglandins Thrombosis Atherosclerosis

Cite This Article

J. Vanitha, Thara, R.Sai Deekshith, K.Sravani, Dr.D.Nagaswetha, "Navigating the Double- Edged Sword of Diclofenac: Pain Relief and Associated Cardiovascular Safety," International Journal of Scientific Research in Engineering and Management, vol. 9, no. 1, Jan 2025. https://doi.org/10.55041/IJSREM41088

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Publication Date

1/25/2025

Peer Review Type

Double-Blind Peer Review

Review Rounds: 2

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The authors declare no conflict of interest related to this research work.

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