One Pot Multicomponent Synthesis of Amino Pyrazole Promoted by Imidazole and Bioevluation

One Pot Multicomponent Synthesis of Amino Pyrazole Promoted by Imidazole and Bioevluation

G. Giribabu1, Dr. KRISHNARAO1*

1*.Department of organic chemistry, PRISM PG&DG College (Affiliated to Andhra University), Visakhapatnam, India, 530016

ABSTRACT:

 In the present study and followed by conventional method, an efficient and design synthesis a novel series of 5-Amino-1,3-diphenyl-1H-pyrazole-4-carbonitrile derivatives. These derivatives can be obtained by Phenyl hydrazine, aromatic aldehydes, and malononitrile in presence of base catalyst Imidazole in ethanol as a solvent at reflux. All the newly obtained derivatives were evaluated by the advanced spectroscopic analysis such as 1HNMR, 13CNMR and LCMS and structural determination of titled analogous were calculated by elemental analysis. In addition to the newly synthesised compounds were examined by their anti-microbial activity

KEYWORDS:

Phenyl hydrazine, aromatic aldehydes, and malononitrile, 5-Amino-1,3-diphenyl-1H-pyrazole-4-carbonitrile , imidazole , anti-microbial activity