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Stream/Area:
-
Subject:
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Paper ID:
10.55041/IJSREM.ISTCESD033
Volume:
10 |
9 |
Sep 2026
Pages:
1-10
Publication Frequency:
Monthly (12 issues per year)
License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.
Department of Chemistry,
Late Pushpadevi Patil Arts & Science College, Risod, Dist-Washim, MS India
Department of Chemistry,
Late Pushpadevi Patil Arts & Science College, Risod, Dist-Washim, MS India
In recent years, quinone imine ketals (QIKs) have been used as outstanding organic synthons for the construction of complex organic molecules as they were equipped with varied functional groups (C=N, C=C and ketal etc.). Unravelling the site selectivity (chemo-, regio- and stereo-selectivity) of QIKs is not only a very noteworthy, but also a thought-provoking research topic. The preparation methods of QIKs and its applications in organic synthesis needs to be explored as very fewer reports were available in the literature.1 Since the quinone imine ketals (QIKs) contains conjugated carbon-nitrogen double bonds in the molecular structure (C=N) and carbon-carbon double bond (C=C) along with ketal functional group, there may be competition among all these functional group sites for the reaction. During participation of these sites in the reaction, there are great challenges associated in realizing their high-selectivity reactions (chemo-selectivity, regioselectivity, and stereo-selectivity) (Scheme 1). In recent years, many research groups worldwide have successively established diverse effective synthetic strategies towards construction of novel and complex organic molecules using quinone imine ketals (QIKs). Furthermore, unravelling new reactions to accomplish site-selective reactions of QIKs, and their application in constructing the novel and complex organic molecules will still be a very highly attractive research topic of academic significance. The synthetic methods for quinone imine ketals (QIKs) and their synthetic applications are summarized in this section.
KEYWORDS
The quinone imine ketal (QIK) has a multifunctional structure with C=N, C=C and ketals, etc. functional groups. In recent years, they have been used in the synthesis of novel, complex organic molecules under the catalytic conditions of achiral/chiral catalysts. Methodological research of QIK focuses on N, C1, C2, C3, ketal-site selective reaction, but there is very little research on the application of QIK to synthesize active drug molecules. The future research on QIK will further explore the site-selective reactions, their applications and photocatalytic approaches. It is potentially one of the hot and challenging research topics.
1. Teng L. Chin. J. Org. Chem. 2020, 40, 2678~2691 2. (a) Chou C.-T.; Swenton J. S. J. Am. Chem. Soc. 1987, 109, 6898. (b) Swenton J. S.; Bonke, B. R.; Chen C.-P.; Chou C.-T. J. Org. Chem. 1989, 54, 51. (c) Swenton J. S.; Shih C.; Chen C.-P.; Chou C.-T. J. Org. Chem. 1990, 55, 2019. (d) Swenton J. S.; Bonke B. R.; Clark W. M.; Chen C.-P.; K. V. J. Org. Chem. 1990, 55, 2027. (e) Dalidowicz P.; Swenton J. S. J. Org. Chem. 1993, 58, 4802. 3. (a) Kerr M. A. Synlett. 1995, 1165. (b) Banfield S. C.; England D. B.; Kerr M. A. Org. Lett. 2001, 3, 3325. (c) Banfield S. C.; Kerr M. A. Can. J. Chem. 2004, 82, 131. 4. (a) Kerr M. A. Synlett. 1995, 1165. (b) Banfield S. C.; England D. B.; Kerr M. A. Org. Lett. 2001,3, 3325. (c) Banfield S. C.; Kerr M. A. Can. J. Chem. 2004, 82, 131. (d) Chuang K. V.; Navarro R.; Reisman S. E. Chem. Sci. 2011, 2, 1086. 5. Dohi T.; Hu Y.; Kamitanaka T.; Washimi N.; Org. Lett. 2011, 13, 4814. 6. Wang L.; Fan R. Org. Lett. 2012, 14, 3596. 7. Shu C.; Liao L.-H.; Liao Y.-J.; Hu X.-Y.; Zhang Y.-H.; Yuan W.-C.; Zhang X.-M. Eur. J. Org. Chem. 2014, 21, 4467. 8. Jiang F.; Zhang Y.-C.; Sun S.-B.; Zhou L.-J.; Shi F. Adv. Synth. Catal. 2015, 357, 1283. 9. Liu T.; Liu J.; Shen X.; Xu J.; Nian B.; F. Synthesis 2019, 51, 1365 10. Halder P.; Humne V. T.; Mhaske S. B. J. Org. Chem. 2019, 84, 1372.
Publication Date
9/28/2026
Peer Review Type
Double-Blind Peer Review
Review Rounds: 2
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