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ArticlePeer ReviewedOpen AccessPlagiarism Passed
Paper ID:IJSREM44128

Role of Genomics and Proteomics in Alzheimer’s Disease

Stream/Area:

-

Subject:

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Paper ID:

IJSREM44128

Volume:

9 |

4 |

Apr 2025

Pages:

Publication Frequency:

Monthly (12 issues per year)

DOI
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10.55041/ijsrem44128

License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.

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Abstract

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline, and its underlying mechanisms involve intricate interactions between genetic and proteomic factors. Genomics and proteomics play a crucial role in understanding Alzheimer’s disease by identifying genetic risk factors. Recent advancements in genomics and proteomics have enabled researchers to develop deeper into the molecular pathways implicated in AD. Genomic studies have uncovered various genetic variants associated with increased risk for AD, particularly in genes such as APP, APOE, TREM2, CLU, CD33, PSEN1 & 2 proteins like Aβ, Tau. Our current understanding of AD pathologies involves various hypotheses, such as the cholinergic, amyloid, tau protein, inflammations, etc.

KEYWORDS

Alzheimer’s disease Genes (APP APOE CLU TREM2 CD33 PSEN1&2) Proteins (Aβ Tau

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4/9/2025

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