Scorpion Venom Components as an Anticancer Agent: Phytochemical Characterization and Evaluation of Cytotoxic Activity

The present study highlights the significant anticancer potential of scorpion venom and its bioactive components. Phytochemical and biochemical characterization confirmed the presence of biologically active peptides, neurotoxins, chlorotoxins, and ion channel-modulating compounds that contribute to its cytotoxic activity against cancer cells. The venom demonstrated concentration-dependent inhibition of cancer cell viability, indicating strong cytotoxic and antiproliferative properties. The observed anticancer effects were mainly associated with apoptosis induction, mitochondrial membrane disruption, cell cycle arrest, inhibition of angiogenesis, and suppression of tumor invasion and metastasis. These mechanisms collectively support the therapeutic value of scorpion venom-derived peptides in cancer treatment. The study also revealed that venom peptides possess selective interactions with cancer-associated ion channels and signaling pathways, making them promising candidates for targeted anticancer therapy. Comparison with previously reported literature further confirmed the effectiveness of scorpion venom against various cancer cell lines including breast cancer, colorectal cancer, lung cancer, prostate cancer, and cervical cancer. Although further investigation is necessary to ensure safety and clinical applicability, the present findings suggest that scorpion venom represents a valuable natural source of novel anticancer compounds with considerable pharmaceutical potential.

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