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Stream/Area:
-
Subject:
-
Paper ID:
IJSREM62426
Volume:
10 |
5 |
May 2026
Pages:
1--
Publication Frequency:
Monthly (12 issues per year)
License:International Journal of Scientific Research in Engineering and Management follows the Creative Commons Attribution 4.0 (CC BY 4.0) License, allowing free use and distribution with proper attribution.
Department of chemistry
Patna University
Department of chemistry
Patna University
Biguanide are versatile nitrogen rich organic compounds with broad applications in medicinal chemistry, coordination chemistry and catalysis. The parent biguanide molecule, C2N5H7, acts as a nitrogen donor bidentate ligand, featuring two units that enable strong chelation with metal ions, leading to the formation of stable complexes. Their ability to coordinate transition metals has facilitated the design of metal-biguanide complexes with remarkable biological and catalytic properties. These complexes display diverse coordination modes influenced by steric and electronic factors, resulting in distinct physiochemical and magnetic behaviours. Spectroscopic and crystallographic investigations reveal rich structural variations, while computational studies offer insight into electronic configurations and reactivity patterns. Metal biguanide systems have been examined for antimicrobial, anticancer and catalytic roles highlighting their importance in contemporary chemistry. This work outlines the synthesis and characterization of biguanide based metal complexes, underlining their relevance in material science and medicinal research.
KEYWORDS
On the basis of a stoichiometric, spectral studies (IR and UV Spectra) and physiochemical properties. Octahedral structure have been proposed for Cobalt dibenzylamine dibiguanide sulphate Complex. The proposed structure of the Cobalt dibenzylamine dibiguanide sulphate Copper ethylene dibiguanide sulphate is as follows
1. Melander B. Pharmacology of the influenza suppressant N1, N1-anhydrobis (Β-hydroxyethyl) biguanide-HCL (ABOB) Toxicol. appl. Pharmacol. (1959). 2. Kathuria, D, D.Raul A, Wanjari, P, V.Bharatam, P. “Biguanides: species with versatile therapeutic applications,.” European Journal of Medicinal Chemistry. 2021;5:219. 3. Morain, P, Abraham, C, Portevin, B, U. De Nanteuil G. “Biguanide-atovaquone synergy against plasmodium falciparum in vitro,.” Antimicrobial Agents and Chemotherapy,. 1994;46:732. 4. Jones, K, A.Ward S. “Biguanide-atovaquone synergy against plasmodium falciparum in vitro,.” Antimicrobial Agents and Chemotherapy. 2001;46:2700. 5. Schafer, G. “Biguanides. A Review of History, Pharmacodynamics and Therapy,.” Diabetes & Metabolism. 1983;9:148. 6. Ray P. . ChemRev. 1964;13:613. 7. Friedrich S, Montash. . 1888;9:227.
Publication Date
5/3/2026
Peer Review Type
Double-Blind Peer Review
Review Rounds: 2
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