Synthesis, Characterization and Antimicrobial Activity of N-(5-(4-(methylsulfonyl) benzyl)-1, 3, 4-thiadiazol-2-yl)-1-Phenylmethanimine Promoted by MSA

Synthesis, Characterization and Antimicrobial Activity of N-(5-(4-(methylsulfonyl) benzyl)-1, 3, 4-thiadiazol-2-yl)-1-Phenylmethanimine Promoted by MSA

M.N. V. Sarat1, Ch.Jyothi1. Dr.N.Krishnarao1*,

1*.Department of organic chemistry, PRISM PG&DG College (Affiliated to Andhra University), Visakhapatnam, India, 530016

Corresponding Author Email.ID: naallakrishnarao@gmail.com

ABSTRACT:

Schiff bases are multipurpose ligands that are created when primary amines condense with carbonyl groups. N-(5-(4-(methylsulfonyl) benzyl)-1, 3, 4-thiadiazol-2-yl) Synthesis MSA promotes -1-phenylmethanimine, which is available When ethanol and acetic acid reflux, 5-(4-(methylsulfonyl) benzyl)-1, 3, 4-thiadiazol-2-amine reacts with aromatic aldehyde. 2-(4-(methylsulfonyl) phenyl) acetic acid and thiosemicarbaide in con H3PO4 in DMF as solvent at 750C can be converted to the chemical 5-(4-(methylsulfonyl) benzyl)-1, 3, 4-thiadiazol-2-amine. All of the mentioned analogous were assessed using sophisticated spectroscopic techniques such 1HNMR, 13CNMR, and LCMS, and elemental analysis was used to determine their structural makeup. Additionally, the antimicrobial activity of the newly synthesized compounds was evaluated.

KEYWORDS:

5-(4-(methylsulfonyl) benzyl)-1, thiosemicarbaide, substituted aryl aldehyde, Schiff’s base, MSA, bioevluation.