Synthesis of 2, 3-Disubstituted Quinazolinones- 4-(3h)-Ones Promoted by Tio2 as a Catalyst and Study of Antimicrobial Activity

Synthesis of 2, 3-Disubstituted Quinazolinones- 4-(3h)-Ones Promoted by Tio2 as a Catalyst and Study of Antimicrobial Activity

K. Srinu1, B. Ishwarya Laxmi 1, Dr.N.Krishnarao1*

1*.Department of organic chemistry, PRISM PG&DG College (Affiliated to Andhra University), Visakhapatnam, India, 530016

ABSTRACT:

         The synthesis of a series of 2, 3-di-substituted quinazolin-4-(3H)-ones derivatives has been accomplished in a single pot by reacting 2-amino-N-phenyl benzamide with a variety of substituted aromatic aldehydes while using ethanol as a solvent and TiO2 a Lewis acid catalyst. This process is straightforward and effective. In addition to the derivatives assessed by antibacterial activity, the final derivatives can be assessed by 1HNMR, 13CNMR, and mass. This approach offers a number of benefits, including a high yield, a quick reaction time, mild reaction conditions, ease of operation, an easy work-up process that is environmentally benign, and the development of non-chromatographic methods for product purification.

KEY WORDS:

2-amino-N-phenyl benzamide, substituted aromaticaldehyde, TiO2,2,3-disubstituted   quinazolin-4(3H)-ones, anti-microbial activity