SYNTHESIS OF 2, 3-DISUBSTITUTED QUINAZOLINONES- 4-(3H)-ONES PROMOTED BY Zr (NO3)2 AS A CATALYST AND STUDY OF ANTIMICROBIAL ACTIVITY

In conclusion, a series of named derivatives have been produced by improving a one-pot, one-step, multicomponent process comprising 2-amino-N-phenylbenzamide, substituted aromatic aldehydes, and Zr(NO3)2 under solvent conditions like ethanol. This procedure is quick, simple, practical, and eco-friendly. For the synthesis of 2, 3-diphenylquinazolin-4(3H)-ones, this technique is effective. High to excellent yields, high reaction rates, avoidance of hazardous organic solvents, ease of operation, straightforward catalyst separation and recycling, large-scale synthetic applicability, the production of water as green waste, excellent atom economy, high reaction mass efficiency, and low E-factor are some of this protocol's notable features. Furthermore, derivatives 3e and 3f shown exceptional efficacy against both bacterial and fungal strains. In contrast to activity, the remaining derivatives displayed modest activity.          

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