Synthesis of Chalcone Derivatives and its Antimicrobial Activities

To investigate the in vitro antibacterial activity of these chalcones against Gram-positive and Gram-negative bacteria as well as fungi, a series of five chalcones that closely mimic those found in nature were created. By the Claisen-Schmidt condensation and a green chemistry procedure that used sodium hydroxide as a catalyst in clean water, chalcones were produced from acetophenone and substituted benzaldehydes with good yields. Amoxicillin and fluconazole were used as standards for the antimicrobial assessment, which was done using the filter paper disc plate technique on a set of chosen bacteria. The structure of the generated derivatives has been determined by employing FTIR Spectroscopy, NMR, and other physicochemical characteristics. These synthesized chalcones showed the expected antibacterial action after being tested for it. This green procedure is the most practical, effective, and environmentally friendly method for the synthesis of chalcones by the Claisen- Schmidt condensation because it is simple to synthesize and purify these chalcones and because high yields are observed. The future development of chalcone derivatives as commercial antibacterial medicines is quite promising.