USE OF CURCUMIN IN PARKINSON’S DISEASE

Parkinson’s disease an age-associated slowly progressive neurodegenerative disease clinically characterized as a movement disorder. The motor symptoms in PD arise due to selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum. In recent years increasing evidence supports the pharmaceutical potential of curcumin against Parkinson disease.[1] Curcumin is a polyphenol and an active component of turmeric (Curcuma longa), a dietary spice used in Indian cuisine and medicine. Curcumin exhibits anti-oxidant, anti-inflammatory , crosses the blood-brain barrier . Previous studies reported the neuroprotective properties of curcumin in in vitro and in vivo Parkinson’s disease models induced by several different environmental factors such as neurotoxins and genetic factors including α-synuclein, PINK1, DJ-1, and LRRK2.[2] This article reviews the therapeutic potential of curcumin in PARKINSON’S disease.